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Year : 2019  |  Volume : 11  |  Issue : 3  |  Page : 122-126

The effects of different durations of zinc oxide–Turmeric dressing application on wound toward neovascularization and expression of macrophage marker antibody and Cyclooxygenase-2: An In vivo study

1 Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
2 Department of Dental Materials, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
3 Department of Biochemistry and Molecular Biology, Faculty of Medicine, Brawijaya University, Malang, Indonesia
4 Department of Oral and Maxillofacial Pathology, Faculty of Dental Medicine; Graduate Student of Basic Medical Science Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
5 Department of Pediatric Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

Correspondence Address:
Dr. Asti Meizarini
Department of Dental Materials, Faculty of Dental Medicine, Universitas Airlangga, Mayjen Prof. Dr. Moestopo Street 47, Surabaya 60132
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jioh.jioh_31_19

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Background: Zinc oxide–turmeric dressing was known to have better anti-inflammatory properties than zinc oxide–eugenol dressing, but the optimal application duration is yet to be discovered. Aims: This study aimed to determine the optimal application duration of zinc oxide–turmeric dressing through molecular observation of neovascularization and expression of MAC387 and cyclooxygenase-2 (COX-2) during wound healing process in rat model. Materials and Methods: Twenty male Wistar rats were randomly divided into four groups (n = 5), Full-thickness excision of 6x6 mm was made on the dorsal area of all subjects and following the excision: the control (C) group was left undressed, while treatment groups was dresed with zinc oxide turmeric dressing for 3 days (T3 group), 5 days (T5 groups), and 7 days (T7 groups) prior to being sacrificed on day 7. All subjects were sacrificed on day 7. Hematoxylin-eosin staining and immunohistochemistry staining were performed to identify the neovascularization and MAC387 and COX-2 expressions. Data obtained were analyzed with analysis of variance and least significant difference test. Results: There was a significant higher neovascular number, higher MAC387 expression, and lower COX-2 expression in T5 and T7 groups compared to the C group (P < 0.05). Conclusions: The application of zinc oxide–turmeric wound dressing for 5 and 7 days could increase both neovascularization and MAC387 expression and also decrease COX-2 expression on the observation day in day 7. The optimal application duration is 5 days.

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