|Year : 2019 | Volume
| Issue : 4 | Page : 165-171
A review on the prevention of inflammatory periimplant diseases
Claudio Passariello1, Dario Di Nardo2, Antonella Polimeni2, Luca Testarelli2
1 Department of Public Health and Infectious Diseases, “Sapienza” University of Rome, Piazzale Aldo Moro 5, Rome, Italy
2 Department of Oral and Maxillo Facial Sciences, “Sapienza” University of Rome, Via Caserta 6, Rome, Italy
|Date of Web Publication||14-Aug-2019|
Dr. Dario Di Nardo
Department of Oral and Maxillo Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome.
Source of Support: None, Conflict of Interest: None
Background: An impressive number of dental implants are inserted worldwide. Evolution in dental implants and simplification of surgical techniques allowed a significant increase in the number of dentists involved in implant surgery. Most of them are general dentists, are not always sufficiently formed and experienced, frequently use low-quality implants, do not adopt the proper patient selective criteria, do not adequately monitor and maintain the inserted implants, and do not report their own statistics to the dental community. Consequently, the incidence of inflammatory periimplant diseases (IPDs) has progressively increased to values significantly higher than those previously indicated by the scientific literature. Materials and Methods: Two main literature searches were undertaken in October 2018 in the PubMed Website database. Only articles written in English and published from 2008 onward were considered; “Clinical Trial,” “Meta analysis,” “Observational study,” “Review,” and “Validation study” were selected as article type filters. The following keywords were used in the searches: “Peri implantitis prevention” and “Dental implant failure prevention.”Results: Preventive measures are analyzed according to the different factors that can favor the occurrence of an infection. The factors are divided into (i) implant dependent, (ii) patient dependent, and (iii) surgeon dependent. Conclusions: Scientific and clinical data confirm that when materials are selected with care, patients are carefully evaluated for factors of risk and attitude to adhere to the necessary maintenance program, and operative protocols and maintenance programs are respected dental implants can be attractive and effective tools for oral rehabilitation. Nevertheless, dentists and patients should have greater awareness that in many cases the decision to utilize dental implants cannot be taken lightly.
Keywords: Periimplantitis, Periimplant Mucositis, Prevention
|How to cite this article:|
Passariello C, Di Nardo D, Polimeni A, Testarelli L. A review on the prevention of inflammatory periimplant diseases. J Int Oral Health 2019;11:165-71
|How to cite this URL:|
Passariello C, Di Nardo D, Polimeni A, Testarelli L. A review on the prevention of inflammatory periimplant diseases. J Int Oral Health [serial online] 2019 [cited 2019 Aug 23];11:165-71. Available from: http://www.jioh.org/text.asp?2019/11/4/165/264431
| Introduction|| |
Implant dentistry has emerged during the last decades as one of the most successful techniques for oral rehabilitation.,,,, Modern oral implants, if adequately inserted and maintained in rigorously selected and instructed patients, guarantee high success rates and long-term survival, although they can undergo inflammatory periimplant diseases (IPDs) and fail.,,,,,,,
In a recent review focusing at the evolution of implant dentistry and its future perspectives, Buser et al. properly evidenced that the picture suggested “by professional boards of periodontists that the incidence of biologic complications, and more specifically of peri-implantitis, may be up to 50%, has shaken the dental community” and “holds a certain risk of damage to the reputation of implant dentistry.”
According to the same authors, “the high prevalence of peri-implantitis reported by some authors is related to a scientific flaw.” Nevertheless, daily clinical experience and several reports from the literature, which will be analyzed further in this article, indicate that the clinical relevance of IPD is underestimated as a consequence of different factors.
Success rates of dental implants are generally estimated according to results obtained by university-based groups with high clinical experience, performing maintenance and follow-up programs.,,,
During the last 10–15 years, the number of dentists involved in implant surgery has progressively expanded, with a significant increase of the number of general dentists who, in many cases, are not provided with specific clinical training and adequate skill and experience., Data of the literature show that when dental implants are positioned by dentists lacking diagnostic and clinical experience, training, and specific skills, they have significantly higher failure rates.,,,
The same period witnessed, at least in Europe, an exponential diffusion of the so-called “low-cost dental clinics” that, in many cases, found their expectation of commercial success on dental implant–based rehabilitations.
As most general dentists and those who work in “low-cost dental clinics” seldom perform dental implant maintenance programs and long-term follow-up of patients, and generally do not publish their own statistics in scientific journals, failures due to IPD in these cases are largely misunderstood.
Moreover, it must be considered that most of the studies performed in the past evaluated clinical outcomes of dental implants based on survival rates, and assumed that an implant is not failed until it is functionally valid.,,,,,, Such an approach is misleading: in fact, a surviving implant is not necessarily a healthy implant.,,,
Recent reports show that when functionally valid implants (i.e., dental implants loaded with a prosthesis in the absence of subjective symptoms and functional limitations) are examined for conditions of periimplant tissues, the prevalence of periimplantitis results as high as about 35% at the patient level and about 20% at the implant level.,,
Once considered that only two main causes of progressive periimplant bone resorption have been extensively investigated in the past (i.e., functional overload and infection), and that at present most authors consider that the role of overload (in the absence of inflammation) has been largely overestimated,, it must be concluded that periimplantitis is by far the most relevant menace to periimplant tissue health,, and that concrete, coordinate measures should be adopted in everyday practice to effectively reduce its incidence.
| Materials and Methods|| |
This non-systematic review intended to analyze selected literature reports dealing with technical and clinical procedure having an influence on the prevention of IPD in order to give the reader synthetic and updated key information ready to be applied to daily clinical practice and to perform implant dentistry with high probability of long-term success.
It was consequently decided to perform literature searches using only general terms expected to be as inclusive as possible. Such an approach could have limited the possibility to retrieve articles dealing with very specialized aspects of the argument and with basic science knowledge, which nevertheless were not within the aims of this review article.
Two main literature searches were undertaken in October 2018 in the PubMed Website database. Only articles written in English and published from 2008 onward were considered; “Clinical Trial,” “Meta analysis,” “Observational study,” “Review,” and “Validation study” were selected as article type filters. The following keywords were used in the searches: “Peri implantitis prevention” and “Dental implant failure prevention.” The two searches retrieved 213 and 159 articles, respectively, including several replicates. A first selection was made by the authors by reading the titles and abstracts from these results to identify articles dealing with the selected topics of this review. For articles appearing to be of interest, or for which the title and abstract did not allow to make a clear decision, the full report was assessed. In this way, 123 articles were selected overall. Reference lists of these articles were hand-searched for additional articles.
The last complementary checkup for newly published articles within the topic was performed in April 2019.
| Discussion|| |
IPDs are bacterially driven inflammatory processes that can be favored by different factors, thus requiring an articulated net of preventive measures to be carefully adopted. These factors can be divided into (i) implant dependent, (ii) patient dependent, and (iii) surgeon dependent.
At present, a plethora of different dental implant systems are available worldwide. Only in Italy, about 60 dental implant manufacturers are active and in several cases these implants are inadequately designed and poorly controlled.
Studies performed between the middle 1980s of the last century and the beginning of the new millennium allowed to identify moderately rough titanium surfaces as the gold standard for optimal osseointegration.,,,, The growing need for multiple prosthetic connection solutions determined success of the two-piece implant systems, although creation of the implant–abutment interface (IAI) revealed risky by enabling bacteria to penetrate inner parts of the implant, which can act as an infective reservoir to promote IPD.,,
Although internal hexagon connections characterizing modern implants make the IAI less accessible to bacteria, and although the introduction of conical connections enabled to significantly reduce gap dimensions at the IAI, all types of connections, when tested under charge or evaluated clinically, show some degree of bacterial microleakage.,
Experimental data show that bacterial microleakage is inversely proportional to torque used to tighten the abutment,, and that abutments made of zirconia and castable abutments enhance the risk. It can consequently be concluded that titanium-to-titanium pre-machined abutments should be privileged.
The region where fixture, abutment, and prosthesis meet is a very delicate one: different materials come in intimate contact in direct proximity to the place where gingival epithelium, connective tissue, and bone work together to repair/maintain tissue integrity. Such a variety of juxtaposed surfaces is very attractive for many different bacterial species, thus contributing to enhance infective risk.
It is not by chance that a lot of work was performed to understand the histological characteristics of periimplant marginal tissues and to optimize/modify the implant collar so that marginal bone is preserved and bacterial biofilm formation is minimized. Moderately rough titanium surfaces play an osteoconductive role and undergo optimal osseointegration without enhancing bacterial biofilm accumulation. Rough titanium collars minimize marginal bone remodeling and promote bone and soft connective tissue formation. Marginal bacterial biofilm accumulation is undoubtedly the necessary condition for IPD initiation and the possibility for bacteria to access intra-implant reservoirs is probably the way they use to have an easier access to marginal bone.
Different strategies to reduce the susceptibility of dental implants to bacterial colonization have been investigated. Laser ablation of titanium implant surfaces was shown to reduce the amount of biofilm formed by different pathogens as compared to sandblasted titanium surfaces. Anatase-coated implant collars were shown to reduce marginal bone loss and to prevent colonization by Tannerella forsythia, as compared to standard implants.
Bacterial biofilms formed in a 96-hour time course on titanium discs coated with zinc oxide or zinc oxide and hydroxyapatite nanoparticles were reduced in mass and viability as compared to uncoated titanium.
Glassy coatings enriched with antimicrobials significantly reduced bacterial colonization of the surfaces and bone loss in an experimentally induced periimplantitis animal model.
Shahi et al. immobilized tetracycline-containing fibers at the surface of implants obtaining a significant, although transient, antibacterial activity. Wang et al. developed a silica-based gentamicin nanodelivery system cross-linked to oxidized titanium.
Binding of bioactive peptides to titanium is being actively investigated to obtain long-lasting antibacterial activity and to speed up osseointegration processes in the absence of toxic effects.,
Considered that IPDs are sustained by different microorganisms and characterized by different pathogenic mechanisms, it seems reasonable that the aforementioned strategies, once validated and appropriately coupled, could prove effective in reducing the incidence of IPD, and that implants with functionalized surfaces could be the materials of choice for cases characterized by relevant factors of risk.
The decision to submit a patient to a dental implant–supported rehabilitation should carefully consider factors relevant for the onset of IPD: (i) predisposing and risk conditions, and (ii) patient’s care and attitude for oral hygiene.
Several authors addressed the question of risk factors and their relative and cumulative relevance in the decision process.,,
The question whether a history of periodontal disease is a factor of risk for IPD or not is crucial and has been extensively debated in the literature and deserves special attention because periodontitis is a highly prevalent cause of partial/total edentulism (i.e., the condition that gives indication to implant-based rehabilitation).,,
Most authors agree that a previous history of periodontitis is a factor of risk for IPD,,,, and epidemiologic data indicate that patients with a history of periodontitis have a higher prevalence of periimplantitis than healthy patients, but the underlying mechanisms are not well defined. The assumption that the pathogenic microbiome of periodontally affected sites diffuses to the periimplant environment causing IPD is not scientifically supported. In patients treated for aggressive periodontitis, periodontal pathogens can colonize the periimplant environment in the absence of IPD. The microbiomes of adjacent periodontal and implanted sites are characterized by low degrees of congruence, and only a minority of dental implants adjacent to periodontal sites positive for putative pathogens included in the red complex resulted positive for the same microorganisms, with the most abundant species in the two environments being constantly distinct.
Recent studies show that patients with a previous history of periodontal disease are less compliant to maintenance programs and oral hygiene measures than healthy subjects, and that consequently a history of periodontitis and its severity are factors influencing the compliance risk profile.
Success rates for dental implants are influenced also by specific site-related factors including the periodontal condition and the level of bone crest in relation to the cementoenamel junction of adjoining teeth at the time of restoration. Interestingly, the risk associated with insertion of an implant adjacent to a periodontally affected tooth results significantly higher than the one associated with a generic history of periodontitis (odds ratios 8.0 and 2.4, respectively).
Overall, when periodontal disease is considered as a risk factor in the implant decision-making process, it cannot be considered as a static factor but it should be rather related to a number of other parameters including patient’s hygienic attitude and understanding of the relevance of maintenance, site-specific conditions, and the conditions of adjoining teeth.
Even in the absence of periodontal disease, inadequate oral hygiene and the presence of abundant dental biofilm are factors of risk for IPD. Patients with good oral hygiene develop IPD if implants are positioned so that their hygienic maintenance is difficult.
A monocentric clinical study on 2673 implants in 1427 patients followed for a mean of 5.3 years showed a statistically significant association between secondary failures due to periimplantitis and individual attitude to oral hygiene.
Cigarette smoking is considered by most authors as a major factor of risk for IPD., Negative effects of cigarette smoking are dose dependent, and smokers were estimated to have up to a three to four folds higher risk of developing periimplantitis than nonsmokers, associated with significant differences in the two microbiomes. Patients should consequently be encouraged to stop/reduce smoking before implant therapy.
The role of alcohol consumption as a risk factor for dental implants is controversial. Several clinical studies addressed this question but only a minority of them identified alcohol consumption as an evident factor of risk.,, Unlike smoking and alcohol abuse, alcohol consumption is an extremely variable behavior (frequency, type, amount), and these variables are not constantly and univocally considered in the literature.
An experimental study in rats showed that prolonged and excessive alcohol intake significantly impaired osseointegration of titanium dental implants inserted in the femur. 
In a recently published review, the authors put in evidence that heavy alcohol consumption exacerbates the effects of tobacco. On the basis of available data, it appears reasonable to suggest caution in inserting dental implants in heavy alcohol consumers/abusers.
The role of diabetes as a factor of risk for IPD is widely debated. A recently published systematic review, specifically addressing this question, concluded that adequately controlled diabetes is not a factor of risk, whereas poor glycemic control favors impaired osseointegration, elevated risk of IPD, and implant failure.
According to a meta-analysis performed by Monje et al., patients with diabetes have a 50% higher risk to develop periimplantitis, but not periimplant mucositis and, when only nonsmokers are considered, diabetic patients with hyperglycemia have a 3.39-fold higher risk for periimplantitis as compared to those with normal glycemia.
In spite of a number of studies performed in different geographic areas, no substantial convergence on worldwide diffused gene polymorphisms correlated to an enhanced risk of IPD was evidenced.,
The potential risk associated with the occurrence of osteonecrosis of the jaw following implant therapy in subjects assuming bisphosphonates has been the object of intense debate in recent years.
Although bisphosphonate treatment is certainly associated with an increased incidence of osteonecrosis of the jaws, the role of dental implants as a trigger for this relevant complication is still uncertain. A recent review on this topic concluded that patients under oral bisphosphonate therapy can be submitted to dental implant therapy, provided all other concurring conditions of risk (age, diabetes, obesity, smoking, immunosuppressive therapies, poor oral hygiene) are carefully evaluated.
The last two decades witnessed a significant evolution in implant materials and surgical procedures that have made implant insertion progressively easier, thus enlarging the number of dentists performing implant surgery. Although it is reasonable that simplified surgical procedures could have positively affected early outcomes of implant surgery, they have certainly contributed to reduce the mean experience of operators.
It is generally agreed that the learning curve of each surgeon is characterized by higher failure rates as compared to later periods., The impact of human factors on dental implant success is intuitive and was clearly demonstrated by monocentric studies evaluating the outcome of all implants placed during a period of time in a single clinical center.,, Albrektsson showed that one single surgeon, although experienced, was responsible for the majority of failed implants within the studied clinical center.
Studying a sample of 9582 implants consecutively placed between 2003 and 2011 during 3448 implant operations at one clinic, and followed up to end of 2015, Jemt observed that implant failures were associated to four significant factors, with the surgeon showing the highest impact on risk (hazard ratio = 2.50).
Surgeon-dependent factors do not end with experience and adherence to protocols. The surgeon is responsible for patient selection and motivation, for surgical planning, for implant placement, and follow-up; he must interface with the prosthodontist and the oral hygienist for long-term maintenance of implants.
Perioperative antibiotic prophylaxis addresses only early-onset infections, whose incidence is low; consequently, the influence of antibiotic prophylaxis on success rates is minimal. At present, there are no established guidelines for antibiotic prescription in dental implant surgery. An investigation performed in Spain revealed that there is no consensus regarding antibiotic prophylaxis in implant dentistry and that the most commonly prescribed regimens are different from those recommend in the literature.
Available data indicate that a single dose of 2g of amoxicillin administered 1 hour before surgery is the regimen of choice for dental implant surgery with no need of further postoperative doses.,
Long-term prevention of IPD requires a patient-specific maintenance program aimed at maintaining a healthy periimplant mucosa and promptly treating sites where periimplant mucositis occurs. Dental implant maintenance should include optimized daily oral hygiene, periodic implant examination and reevaluation of patient-specific risk factors, and periodic professional oral hygiene maintenance. Maintenance programs should be individually designed with a recall period not exceeding 6 months even in healthy, compliant patients.
| Conclusion|| |
Dental implants are attractive and effective tools for oral rehabilitation, but dentists and patients should have greater awareness that in many cases the decision to utilize them cannot be taken lightly. Patients should be carefully evaluated for factors of risk and attitude to adhere to the necessary maintenance program. Dentists should carefully select materials, respect operative protocols, and constantly communicate with their staff to prevent IPD and periimplant tissue damage.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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