JIOH on LinkedIn JIOH on Facebook
  • Users Online: 245
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2021  |  Volume : 13  |  Issue : 2  |  Page : 101-107

Biogenesis of microRNAs and its implication in head and neck pathologies: A Narrative Review


Department of Oral & Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed To Be University, Bhubaneswar, Odisha, India

Correspondence Address:
Dr. Kailash Chandra Dash
Department of Oral & Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed To Be University, Bhubaneswar, Odisha.
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jioh.jioh_226_20

Rights and Permissions

Aim: MicroRNAs (miRNA) are 19–23 nucleotides small non-coding RNAs that regulate gene expression either by silencing or degrading the target gene. Altered miRNAs are associated with various dental and inflammatory diseases. The aim of this review is to provide an insight into the biogenesis, role of miRNA in physiology, and development of dysregulated miRNA which has an impact on hallmarks of cancer. Materials and Methods: A literature review search was made from PubMed, Scopus, and Web of Science databases using the key words biogenesis of miRNA, stem cell culture, oral cancer, circulating miRNAs, autoimmune disorders, and periodontitis. We also included systematically reviewed articles that highlighted the mechanism of silencing of gene and epigenetic modifications by miRNA. Results: Pertaining to various literatures there is definite correlation of miRNA with various pathological conditions occurring in head and neck region. Conclusion: Our review indicates that numerous miRNAs play a key role in diagnosis, prognosis, and therapeutic role in oral diseases. In this context, multitudinous studies are a prerequisite for validation of miRNA as a reliable biomarker in head and neck pathologies and its targeted therapy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed716    
    Printed18    
    Emailed0    
    PDF Downloaded59    
    Comments [Add]    

Recommend this journal