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Year : 2021  |  Volume : 13  |  Issue : 2  |  Page : 115-121

Effectiveness of electrospun Ocimum sanctum nanofibers as an adjunct to scaling and root planning in the management of chronic periodontitis: A randomized controlled clinical trial

Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Gurumoorthy Kaarthikeyan
Department of Periodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, 162, Poonamalle High Road, Tamil Nadu.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jioh.jioh_245_20

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Aim: Research based on periodontal therapy is focused on the use of natural products rather than chemical agents. Ocimum sanctum has been known to possess various medicinal properties. There is only a limited literature available on the therapeutic effectiveness of O. sanctum for the treatment of periodontal disease. Local drug delivery systems allowed for the direct delivery to the diseased site thereby bypassing systemic circulation and hence attaining maximum concentration at the site that requires the drug. The aim of the study was to analyze the effect of O. sanctum on the anti-inflammatory efficiency [interleukin 1-β (IL-1β)] in patients with periodontitis. Materials and Methods: A randomized, controlled, clinical trial was conducted with a sample size of 15 patients to compare the clinical parameters and IL-1β levels in subjects who underwent nonsurgical periodontal therapy along with local application of O. sanctum fibers and those subjects who had undergone non-surgical periodontal therapy alone. Results: From the present study, a statistically significant difference could not be observed in the IL-1β levels or in the clinical parameters between the test and the control groups at the end of 1 month. There was a significant difference in clinical attachment-level gain between groups (P = 0.046). Conclusion: Ocimum sanctum nanofibers provided benefits in terms of reduction in IL-1β levels. Our study concludes that O. sanctum delivers additional benefit when used as an adjuvant in the treatment of periodontitis.

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