Levels of interleukins in patients with chronic kidney disease and periodontitis: A systematic review
Mahmud Mohammed1, Fabiha Jesmin2, Nur Karyatee Kassim3, Siti Lailatul Akmar Zainuddin4, Muhammad Hafiz Hanafi5, Muhammad Imran Kamarudin5, Farizan Ahmad5, K.N.S. Sirajudeen6
1 Department of Conservative Dentistry & Endodontics, Delta Medical College- Dental Unit, Dhaka, Bangladesh
2 Department of Paediatric Dentistry, Delta Medical College-Dental Unit, Dhaka, Bangladesh
3 School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia; Chemical Pathology Department, Hospital Universiti Sains Malaysia, Kelantan, Malaysia
4 School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia
5 School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia
6 Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Malaysia
Nur Karyatee Kassim
School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia and Chemical Pathology Department, Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan.
Source of Support: None, Conflict of Interest: None
Aim: To systematically review the in vivo clinical studies available in the literature evaluating the effect of interleukin (IL) in patients with chronic kidney disease (CKD) and chronic periodontitis (CP). Materials and Methods: A search was initially performed using Scopus, PubMed, and Web of Science databases published from the year 2003 to 2020. Among the keywords used in the search were “periodontal diseases,” “interleukin,” “chronic kidney diseases,” and “inflammation.” After relevant articles were found, a critical assessment was made to select those that met the criteria for the systematic review. Among the inclusion criteria needed for the papers were randomized clinical trials, longitudinal clinical trials, clinical studies, no sample size limits, and only English language articles. Case reports, conference abstracts, and unpublished data were excluded for this study. Result: Based on the keywords, 16 of the relevant articles were listed and seven of them were selected for a systematic review. Conclusion: After reviewing the articles based on their results and conclusion, it can be concluded that serum IL level increased significantly in patients with CKD and CP and periodontal therapy can significantly reduce the level of serum IL. Moreover, the effect of modern periodontal therapy in CKD and CP is still unknown and inflammatory gene expression profile in patients with CKD will still need to be evaluated within different populations.