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Year : 2022  |  Volume : 14  |  Issue : 4  |  Page : 377-381

Efficacy of domestically manufactured remineralizing agent on artificially created surface lesions: A comparative ex-vivo study

1 Department of Conservative Dentistry and Endodontics, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamil Nadu, India
2 Department of Conservative Dentistry and Endodontics, Sri Ramakrishna Dental College, Coimbatore, Tamil Nadu, India
3 Consultant Endodontist, Iyyapanthangal, Chennai, Tamil Nadu, India
4 Department of Conservative Dentistry and Endodontics, Sri Venkateshwaraa Dental College, Ariyur, Puducherry, India

Correspondence Address:
Dr. Chakravarthy S Vineetha
Department of Conservative Dentistry and Endodontics, Sri Ramakrishna Dental College, Coimbatore 641006, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JIOH.JIOH_14_22

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Aim: To compare and evaluate the efficacy of domestically manufactured remineralizing agents on artificially created carious lesions. Materials and Methods: Freshly extracted 60 human maxillary first premolars were used for our in-vitro comparative study. The samples were embedded in acrylic resin such that the surface of enamel is visible for study. These samples were stored in deionized water for 1 month. The surfaces were demineralized to create a subsurface lesion. Samples were then divided using random sampling method into four groups. Each group had a sample size of 15, according to the remineralizing agent used. Group 1—tri-calcium phosphate (β-TCP), Group 2—domestically manufactured nano hydroxyapatite (NHA), Group 3—bioactive glass (BAG), and Group 4—artificial saliva (control). These remineralizing agents were applied on the samples of respective groups for 4 min, at every 24th hour for a duration of 7 days. After which, incubation of the samples was carried out by placing them in artificial saliva. This was done at a temperature of 37°C between every cycle. After completion of seven cycles, Vickers microhardness test was used to measure the surface microhardness. Data were collected and HV values among the groups were compared using one-way analysis of variance. Multiple pairwise comparisons were analyzed using Tukey’s honestly significant difference post hoc tests. Results: Improved surface remineralization was observed in all the three groups. Nano-hydroxyapatite showed highest remineralization. TCP showed better remineralization compared to BAG. Conclusion: Remineralizing efficacy of NHA toothpaste was higher when compared with BAG and β-TCP.

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